Hyperlipidemia Combined 2 C1858308
A disorder with high levels of multiple blood fats, including cholesterol and triglycerides. It commonly affects adults and is usually managed with lifestyle modifications and lipid-lowering medications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Early-onset coronary artery disease
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Tendon xanthomas
(musculoskeletal)Peripheral neuropathy
(neurologic)Obesity
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Statin combination therapy
Combination lipid-lowering therapy using statins with ezetimibe or bile acid sequestrants to achieve more aggressive LDL reduction in mixed dyslipidemia patterns.
Mediterranean diet pattern
Evidence-based dietary approach rich in olive oil, nuts, fish, fruits, and vegetables designed to improve the atherogenic lipid profile characteristic of combined hyperlipidemia.
Additional treatment options
PCSK9 inhibitor therapy
Monoclonal antibody therapy targeting proprotein convertase subtilisin/kexin type 9 for patients with refractory combined hyperlipidemia requiring additional LDL lowering despite maximal statin therapy.
medicationWeight management program
Comprehensive weight loss strategy through caloric restriction and increased physical activity to improve insulin sensitivity and favorably modify the lipid profile in obesity-related dyslipidemia.
lifestyleOmega-3 supplementation
Fish oil or prescription omega-3 fatty acid supplements to specifically address elevated triglyceride levels in combined hyperlipidemia as adjunctive therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hyperlipidemia Combined 2 C1858308?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019.
Ference BA, Ginsberg HN, Graham I, et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease. A consensus paper from the International Atherosclerosis Society. Eur Heart J. 2023.
Sabatine MS, Giugliano RP, Keech AC, et al. Evolocumab and clinical outcomes in patients with cardiovascular disease. N Engl J Med. 2017.
Schwartz GG, Steg PG, Szarek M, et al. Alirocumab and cardiovascular outcomes after acute coronary syndrome. ODYSSEY OUTCOMES Trial. Circulation. 2018.
Medication Comparisons
Compare medications used to treat Hyperlipidemia Combined 2 C1858308. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy