Hypermanganesemia With Dystonia 2 C4310765
A rare disorder causing manganese to accumulate in the body, damaging the nervous system and causing movement problems. Treatment involves chelation therapy to remove excess manganese.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Dystonia
(neurological)Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gait disturbance
(neurological)Tremor
(neurological)Cognitive impairment
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
EDTA chelation therapy
Disodium EDTA chelation therapy binds manganese in the bloodstream, facilitating urinary excretion and reducing manganese accumulation in the brain. This addresses the underlying cause of neurological symptoms.
Manganese-restricted diet
Limiting intake of manganese-rich foods such as nuts, seeds, legumes, and certain green leafy vegetables helps reduce the body's manganese burden. Education on identifying high-manganese foods is essential.
Additional treatment options
Deep brain stimulation
In patients with significant dystonia who do not respond adequately to chelation therapy, deep brain stimulation may help manage refractory movement symptoms. This targets specific brain regions involved in motor control.
surgicalPhysical therapy and rehabilitation
Specialized physical therapy helps maintain motor function, improve balance, and address movement disorders associated with dystonia. Regular therapy sessions can significantly improve quality of life.
physical_therapyBlood manganese and neuroimaging monitoring
Regular blood tests measuring manganese levels combined with periodic brain MRI help assess treatment efficacy and disease progression. Monitoring guides adjustments to chelation therapy intensity.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hypermanganesemia With Dystonia 2 C4310765?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy