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Hyperparathyroidism 1 C1840402

Published: July 22, 2026Updated: August 20, 2026

A condition where overactive parathyroid glands produce excess hormone, leading to high blood calcium levels. It often affects adults and may be treated with surgery, medication, or monitoring.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
E34.9
ICD-11
5A00.0
Body system
endocrine
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue or weight changes

(endocrine)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Hypercalcemia

(endocrine)

Kidney stones

(endocrine)

Bone pain due to osteoporosis

(endocrine)

Neuropsychiatric symptoms (depression, cognitive dysfunction)

(endocrine)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Endocrine management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Parathyroidectomy

Surgical removal of the overactive parathyroid gland(s) is the primary definitive treatment for primary hyperparathyroidism. Pre-operative localization studies guide the surgical approach, and minimally invasive techniques are often employed when feasible.

surgical
3

Calcimimetic therapy

Cinacalcet is a calcimimetic agent that reduces parathyroid hormone secretion by increasing the sensitivity of calcium-sensing receptors. This treatment is particularly useful for patients who are not surgical candidates or have persistent hyperparathyroidism after surgery.

medication

Additional treatment options

Hydration and activity modification

Adequate fluid intake of 2-3 liters daily helps prevent kidney stones, a common complication of hyperparathyroidism. Weight-bearing exercises support bone health, while avoiding prolonged immobility reduces hypercalcemia risk.

lifestyle

Calcium-modified diet

Moderate calcium intake is recommended rather than severe restriction, as the body still requires calcium for essential functions. Working with a dietitian helps balance calcium intake while avoiding high-calcium foods that may exacerbate symptoms.

dietary

Regular biochemical monitoring

For asymptomatic or surgically ineligible patients, regular monitoring of serum calcium, PTH levels, kidney function, and bone density through DXA scans guides treatment decisions and identifies disease progression requiring intervention.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hyperparathyroidism 1 C1840402?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bilezikian JP, Bandeira L, Khan A, Cusano NE. Hyperparathyroidism: Clinical practice guidelines. Lancet Diabetes Endocrinol. 2020.

guideline2020
2

Sundin A, Weber C, Hellman P. Primary hyperparathyroidism: Diagnosis and management. Endocr Rev. 2019.

review2019
3

Mihai R, Donican M, Bradpiece H. Minimally invasive parathyroidectomy versus conventional surgery: A randomized controlled trial. Surgery. 2018.

clinical_trial2018
4

Zhou W, Chen M, Liu W. Surgical outcomes in primary hyperparathyroidism: A systematic review and meta-analysis. J Clin Endocrinol Metab. 2022.

meta_analysis2022

Medication Comparisons

Compare medications used to treat Hyperparathyroidism 1 C1840402. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy