Hyperuricemic Nephropathy Familial Juvenile Type 3 C3280216
A rare inherited kidney disorder characterized by elevated uric acid levels that can damage the kidneys over time. It typically begins in childhood or adolescence. Treatment aims to lower uric acid and protect kidney function.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Flank pain
Hypertension
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gouty arthritis
(renal)Hyperuricemia
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Xanthine Oxidase Inhibitors
Allopurinol or febuxostat reduce uric acid production by inhibiting xanthine oxidase enzyme. This prevents further urate crystal deposition in renal tubules and slows disease progression. Regular monitoring of serum uric acid levels guides dose adjustments.
Low Purine Diet
Restriction of purine-rich foods such as red meat, organ meats, and certain seafood reduces endogenous uric acid production. This dietary modification complements pharmacological therapy for optimal uric acid control.
Additional treatment options
Increased Hydration
High fluid intake of 2-3 liters daily promotes uric acid excretion and reduces crystal formation in renal tubules. Adequate hydration also supports overall kidney function and prevents kidney stone formation.
lifestyleRenal Function Surveillance
Regular assessment of kidney function through serum creatinine, eGFR, and urinalysis monitors disease progression and treatment efficacy. Early detection of declining function allows timely intervention adjustments.
monitoringHerbal Supplements
Certain botanical preparations like tart cherry extract may provide modest anti-inflammatory benefits as adjunctive therapy. These should never replace conventional treatment but may support overall management.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hyperuricemic Nephropathy Familial Juvenile Type 3 C3280216?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy