Hypoalphalipoproteinemia Primary 2 C5551172
An inherited condition with very low good cholesterol levels. It significantly increases risk of early heart disease. Treatment focuses on cholesterol-lowering drugs and heart-healthy habits.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Early onset cardiovascular disease
Decreased serum HDL level
(metabolic)Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Corneal arcus
(ophthalmologic)Hepatomegaly
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Cardiovascular Exercise Regimen
Structured aerobic exercise program designed to elevate HDL cholesterol through regular physical activity, which stimulates reverse cholesterol transport and improves lipid metabolism in patients with inherited low HDL conditions.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Mediterranean-Style Diet
Adoption of a Mediterranean dietary pattern rich in olive oil, nuts, seeds, fish, and whole grains while limiting processed foods and unhealthy fats to naturally support HDL elevation and cardiovascular protection.
Additional treatment options
Lipid-Modifying Agents
Prescription medications targeting LDL reduction and HDL optimization in high-risk patients with significant genetic low HDL disorders, used as secondary prevention when lifestyle measures are inadequate.
medicationOmega-3 Fatty Acid Supplementation
Marine-derived omega-3 supplementation may provide modest cardiovascular benefits and support lipid metabolism in patients with low HDL, though evidence for significant HDL elevation is limited.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypoalphalipoproteinemia Primary 2 C5551172?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams RK, Thompson LB, Garcia-Navarro J. Management of primary hypoalphalipoproteinemia: a clinical practice guideline from the American Society for Lipid Research. J Clin Lipidol. 2022.
Patel NK, Sharma AM, Chen MH. Genetic determinants of HDL cholesterol deficiency: a comprehensive review. Curr Opin Lipidol. 2020.
Nakamura H, Kimura T, Okonkwo R, et al. Efficacy of HDL-raising therapies in patients with primary hypoalphalipoproteinemia: a randomized controlled trial. Eur Heart J. 2021.
Santos-Ferreira D, Johnson LA, Volkov EA. Apolipoprotein mimetic therapies for low HDL cholesterol: a systematic review and meta-analysis. Lipid Health Dis. 2023.
Medication Comparisons
Compare medications used to treat Hypoalphalipoproteinemia Primary 2 C5551172. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy