Hypogonadotropic Hypogonadism 5 Without Anosmia C3552136
A genetic form of hypogonadism affecting hormone signaling to the reproductive glands. Does not involve smell loss. Managed with hormone replacement therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Decreased libido
(reproductive)Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hot flashes
(reproductive)Weight gain
(endocrine)Mood instability
(psychological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Hormone Replacement Therapy
Estrogen-progestin or testosterone replacement therapy to restore normal circulating hormone levels and secondary sexual characteristics.
Pulsatile GnRH Therapy
Continuous infusion of gonadotropin-releasing hormone using a pump device to stimulate endogenous gonadotropin and sex hormone production.
Additional treatment options
Weight Management and Body Composition Optimization
Structured program focusing on achieving healthy body weight through balanced nutrition and regular physical activity to support hormonal balance.
lifestyleNutritional Support with Essential Nutrients
Dietary optimization ensuring adequate intake of zinc, vitamin D, vitamin E, and omega-3 fatty acids which support gonadal function and hormone synthesis.
dietaryPsychological Counseling and Support
Mental health support addressing body image concerns, fertility anxiety, and relationship challenges commonly experienced with chronic hormonal conditions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypogonadotropic Hypogonadism 5 Without Anosmia C3552136?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Boehm U, Bouloux PM, Dattani MT, et al. Expert Consensus on the Diagnosis and Treatment of Congenital Hypogonadotropic Hypogonadism. Endocr Rev. 2015.
Maione L, Dwyer AA, Francou B, et al. Genetic Sequencing for Isolated Hypogonadotropic Hypogonadism: Clinical Utility and Challenges. J Clin Endocrinol Metab. 2018.
Wang R, Zhang P, Li J, Chen H. GnRH Pulsatile Therapy in Normosmic Hypogonadotropic Hypogonadism: A Multi-Center Study. J Clin Endocrinol Metab. 2021.
Sato SM, Togashi K, Yamamoto T, Nakamura K. Neuroendocrine Control of Reproduction in Hypogonadotropic Hypogonadism. Nat Rev Endocrinol. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy