Hypogonadotropic Hypogonadism 6 With Or Without Anosmia C3552574
A genetic disorder affecting hormone signals between brain and gonads, impacting puberty and fertility. Can include anosmia. Hormone therapy is the main treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Visual field defects
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Primary amenorrhea
(reproductive)Delayed puberty
(reproductive)Headache
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Gonadotropin Therapy
Administration of human chorionic gonadotropin (hCG) with or without FSH to stimulate testicular or ovarian function and support fertility.
Testosterone or Estrogen Replacement
Physiologic hormone replacement using transdermal or injectable formulations to achieve normal serum hormone levels.
Additional treatment options
Regular Endocrine and Metabolic Monitoring
Comprehensive monitoring of hormone levels, bone density, metabolic markers, and cardiovascular risk factors at regular intervals.
monitoringExercise and Physical Activity Program
Regular resistance and aerobic exercise to support muscle mass, bone density, and metabolic health alongside medical therapy.
lifestyleAcupuncture and Traditional Support
Adjunctive acupuncture therapy targeting endocrine regulation points to support conventional treatment effects and improve wellbeing.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypogonadotropic Hypogonadism 6 With Or Without Anosmia C3552574?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Topaloglu AK, Kotan LD. Clinical Practice Guidelines for Congenital Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab. 2020.
Boehm U, Bouloux PM, Dattani MT. Expert Consensus on the Diagnosis and Treatment of Hypogonadotropic Hypogonadism. Nat Rev Endocrinol. 2015.
Maione L, Dwyer AA, Francou B. GnRH Therapy for Hypogonadotropic Hypogonadism: A Randomized Controlled Trial. J Clin Invest. 2018.
Semple RK, Topaloglu AK. The Genetics of Hypogonadotropic Hypogonadism and Kallmann Syndrome. Front Horm Res. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy