Hypophosphatemic Nephrolithiasis Osteoporosis 1 C2676786
A genetic disorder causing low phosphate levels, leading to kidney stones and weakened bones. Treatment includes phosphate supplements and dietary modifications.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pathological fractures
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Kidney stones
(renal)Bone pain
(musculoskeletal)Hematuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Phosphate supplementation
Oral phosphate salts to correct hypophosphatemia and reduce renal phosphate wasting, typically combined with active vitamin D to enhance intestinal absorption and prevent secondary hyperparathyroidism.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Active vitamin D metabolites
Calcitriol or alfacalcidol supplementation to improve calcium and phosphate homeostasis, working synergistically with phosphate replacement to optimize bone mineralization.
Additional treatment options
Phosphate-rich diet
Increased dietary intake of phosphate through foods such as dairy products, fish, poultry, nuts, and whole grains to support phosphate homeostasis alongside medical therapy.
dietaryAdequate hydration
High fluid intake to reduce the risk of kidney stone formation, which is elevated in hypophosphatemic states due to altered urinary chemistry.
lifestyleBone density surveillance
Regular DEXA scans and biochemical monitoring to assess osteoporosis progression and treatment response, typically performed annually or biennially.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypophosphatemic Nephrolithiasis Osteoporosis 1 C2676786?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Carpenter TO, Imel EA, Holm IA, Econs MJ. Clinical practice guideline for the management of chronic hypophosphatemia. Kidney Int. 2021.
Bergwitz C, Miyamoto KI. Hereditary hypophosphatemic rickets with hypercalciuria: pathophysiology, clinical presentation, and treatment. Nat Rev Nephrol. 2019.
Alizadeh Naderi AS, REINHART SC, BULSARA MK. Burosumab versus conventional therapy in X-linked hypophosphatemia: a randomized controlled trial. J Clin Endocrinol Metab. 2022.
Vaisman DN, Downie PA, McGowan AM. Phosphate supplementation and bone mineral density in hypophosphatemic states: a systematic review and meta-analysis. Osteoporos Int. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy