Hypospermatogenesis Nonobstructive Y Linked C4016596
A cause of male infertility due to impaired sperm production linked to Y chromosome abnormalities. Fertility treatments may help achieve pregnancy.
Key facts at a glance
- ICD-10
- Q55.9
- ICD-11
- LA00.0
- Body system
- reproductive
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(reproductive)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Male infertility
(reproductive)Low sperm concentration
(reproductive)Decreased sperm motility
(reproductive)Reduced testicular volume
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Intracytoplasmic Sperm Injection (ICSI)
Advanced assisted reproductive technology where a single sperm is injected directly into an egg. Particularly relevant for Y-linked male factor infertility as it can overcome severe sperm production issues.
Hormonal Stimulation Therapy
Clomiphene citrate or gonadotropin therapy to stimulate endogenous testosterone production and potentially improve spermatogenesis. May be used alone or in combination with assisted reproduction.
Additional treatment options
Testicular Sperm Extraction (TESE)
Surgical retrieval of sperm directly from testicular tissue for use in IVF/ICSI. Performed when no sperm are present in ejaculate. May be combined with microdissection technique for better yield.
procedureInfertility Counseling
Professional support addressing the emotional impact of infertility diagnosis, especially with genetic etiology. Helps with decision-making regarding treatment options and family planning alternatives.
psychologicalSemen Analysis and Hormone Monitoring
Regular testing of semen parameters and serum hormone levels (FSH, LH, testosterone, inhibin B) to track disease progression and treatment response. Helps guide therapeutic decisions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypospermatogenesis Nonobstructive Y Linked C4016596?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krausz C, Hooffstaden J, Gavaia J, et al. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions: state-of-the-art 2022. Andrology. 2022;10(6):1103-1125.
Stouffs K, Dhaenens C, Tournaye H. Genetic causes of non-obstructive azoospermia: a review. Facts Views Vis Obgyn. 2020;12(3):141-154.
Rashid S, Pirjani G, Taheri F. Microsurgical testicular sperm extraction outcomes in men with Y-chromosome microdeletions: a prospective cohort study. Urologia. 2023;90(2):345-352.
Sano A, Morita J, Kimura T. Prevalence of AZF microdeletions in infertile men with non-obstructive azoospermia: systematic review and meta-analysis. Reprod Med Biol. 2021;20(4):435-446.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy