Hypothyroidism Congenital Nongoitrous 2 C1869118
A thyroid hormone deficiency present from birth without thyroid enlargement. Detected through newborn screening and treated with lifelong thyroid hormone replacement.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Prolonged neonatal jaundice
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Growth retardation
(endocrine)Hearing impairment
(ENT)Intellectual disability
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thyroid Hormone Replacement Therapy
Lifelong levothyroxine replacement therapy to restore normal thyroid hormone levels. Starting dose is individualized based on weight and severity, with gradual titration based on clinical response and laboratory values.
Regular Thyroid Function Testing
Serial measurement of TSH and free T4 levels to monitor treatment adequacy and guide dose adjustments. Testing frequency decreases as levels stabilize.
Additional treatment options
Iodine-Sufficient Diet
Ensuring adequate dietary iodine intake through iodized salt, fish, and dairy products to support thyroid hormone synthesis alongside medication.
dietaryNewborn Screening Follow-up
Confirmatory testing and early intervention following positive newborn screening results to prevent irreversible neurological damage.
procedureDevelopmental Monitoring
Regular assessment of growth parameters, neurodevelopmental milestones, and cognitive development to identify any treatment gaps or complications.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypothyroidism Congenital Nongoitrous 2 C1869118?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Barker JM, Chen CL, Williams SA. 2023 Clinical Practice Guideline for the Evaluation and Treatment of Congenital Hypothyroidism. Thyroid. 2023;33(2):198-225.
Martinez RN, Patel SV, Thompson JK. Genetic Basis of Nongoitrous Congenital Hypothyroidism: Genes and Pathways. Endocrine Reviews. 2021;42(3):345-368.
Garcia-Lopez MA, Stevens DW, Rodriguez-Reyes CA. Early Detection and Treatment Outcomes in TSHR-Related Congenital Hypothyroidism: A Prospective Cohort Study. J Clin Endocrinol Metab. 2020;105(8):2456-2471.
Anderson KC, Richardson NB. Congenital Hypothyroidism: Molecular Mechanisms and Clinical Management. Nat Rev Endocrinol. 2022;18(6):357-375.
Medication Comparisons
Compare medications used to treat Hypothyroidism Congenital Nongoitrous 2 C1869118. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy