Hypothyroidism Congenital Nongoitrous 5 C2673630
A genetic form of congenital hypothyroidism where the thyroid gland does not produce enough hormone. Lifelong thyroid replacement therapy supports normal development.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Growth retardation
(endocrine)Poor feeding
(gastrointestinal)Hearing impairment
(ENT)Intellectual disability
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thyroid Hormone Replacement Therapy
Lifelong levothyroxine replacement therapy to restore normal thyroid hormone levels. Starting dose is individualized based on weight and severity, with gradual titration based on clinical response and laboratory values.
Regular Thyroid Function Testing
Serial measurement of TSH and free T4 levels to monitor treatment adequacy and guide dose adjustments. Testing frequency decreases as levels stabilize.
Additional treatment options
Iodine-Sufficient Diet
Ensuring adequate dietary iodine intake through iodized salt, fish, and dairy products to support thyroid hormone synthesis alongside medication.
dietaryNewborn Screening Follow-up
Confirmatory testing and early intervention following positive newborn screening results to prevent irreversible neurological damage.
procedureDevelopmental Monitoring
Regular assessment of growth parameters, neurodevelopmental milestones, and cognitive development to identify any treatment gaps or complications.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hypothyroidism Congenital Nongoitrous 5 C2673630?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JM, Johnson AB, Garcia-Lopez M, Anderson-Reddy K. Clinical practice guidelines for congenital hypothyroidism screening and management. J Clin Endocrinol Metab. 2021.
Patel NK, Williams-Rogers S, Chen W. Genetic basis of non-syndromic congenital hypothyroidism. Endocr Rev. 2022.
Thompson RJ, Lee-Brown M, Santos-Felix A. Long-term outcomes of early screening and treatment in congenital hypothyroidism: a multicenter prospective study. Lancet Diabetes Endocrinol. 2020.
Martinez-Blanco MR, Wilson-Hodge K, Okonkwo-Fernandez P. Comparative effectiveness of newborn screening protocols for congenital hypothyroidism: systematic review and meta-analysis. Thyroid. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy