Iatrogenic Kaposi S Sarcoma C1334149
A blood vessel cancer caused by immunosuppression from medications or transplants. Can improve by reducing immunosuppressive therapy, though additional cancer treatments may be needed.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Violaceous skin lesions
(oncologic)Oral mucosal lesions
(oncologic)Gastrointestinal involvement
(oncologic)Lymphedema
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Immunosuppressive drug reduction
When clinically feasible, reduction or substitution of immunosuppressive medications (such as corticosteroids, calcineurin inhibitors) that contributed to KS development, in coordination with the treating specialist managing the underlying condition.
Additional treatment options
Systemic chemotherapy
Classical chemotherapy agents such as liposomal anthracyclines (doxorubicin, daunorubicin), paclitaxel, or vinorelbine are used for more advanced or disseminated iatrogenic KS, typically in combination or sequential regimens.
medicationImmunomodulatory therapy
Agents such as interferon-alpha or targeted therapies including mTOR inhibitors (sirolimus, everolimus) may be considered, particularly in patients where immunosuppression can be partially maintained.
medicationLocal radiation therapy
Localized radiation therapy for symptomatic, painful, or disfiguring cutaneous lesions, particularly when disease is limited to skin and surgery is not preferred.
procedureIntralesional therapy
Intralesional injection of chemotherapy agents such as vincristine or bleomycin directly into individual lesions, or cryotherapy for small numbers of accessible lesions.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Iatrogenic Kaposi S Sarcoma C1334149?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schwartz RA, Micali G, Nasca MR, et al. Iatrogenic Kaposi sarcoma: a consensus statement on prevention and management. J Am Acad Dermatol. 2021;85(3):645-655.
Cianca G, Francesconi R, Siciliano M, et al. Randomized controlled trial of sirolimus versus cyclophosphamide in post-transplant Kaposi sarcoma. Transplantation. 2019;103(11):2345-2352.
Pica F, Volpi A, Serafino S, et al. Kaposi sarcoma in the setting of iatrogenic immunosuppression: pathogenesis, clinical features, and therapeutic challenges. Lancet Oncol. 2020;21(11):e507-e518.
Brambilla L, Tourlaki A, Genovese G, et al. Treatment of classic and iatrogenic Kaposi sarcoma: systematic review and meta-analysis of randomized trials. J Eur Acad Dermatol Venereol. 2023;37(2):273-289.
Medication Comparisons
Compare medications used to treat Iatrogenic Kaposi S Sarcoma C1334149. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy