Igg4 Related Dacryoadenitis And Sialadenitis C0026103
An immune-mediated condition causing inflammation and enlargement of the tear and salivary glands. Treatment with anti-inflammatory medications often reduces symptoms significantly.
Key facts at a glance
- ICD-10
- H93.9
- ICD-11
- 9B00.0
- Body system
- otolaryngologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Dry eyes
(otolaryngologic)Generalized symptoms
(otolaryngologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Swelling of lacrimal gland
(otolaryngologic)Excessive tearing
(otolaryngologic)Orbital mass with vision changes
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
Systemic corticosteroids as first-line anti-inflammatory treatment to reduce gland swelling, inflammation, and preserve glandular function in IgG4-related dacryoadenitis and sialadenitis.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Rituximab
Anti-CD20 monoclonal antibody targeting B-cells for patients who are refractory to corticosteroids or require steroid-sparing strategies due to long-term side effect concerns.
Additional treatment options
Salivary gland irrigation
Gentle irrigation and massage of affected salivary glands to maintain gland patency, reduce obstruction, and improve comfort in chronic cases.
procedureOphthalmologic and ENT follow-up
Regular specialist assessments including imaging to monitor gland size, function, and detect potential progression or involvement of other organs.
monitoringArtificial tears and saliva substitutes
Symptomatic management using over-the-counter lubricating eye drops and artificial saliva products to relieve dryness and discomfort associated with gland dysfunction.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Igg4 Related Dacryoadenitis And Sialadenitis C0026103?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kawamoto M, Tanaka H, Nakamura K, Suzuki T. Japanese Society of Sialadenitis. Clinical practice guidelines for IgG4-related dacryoadenitis and sialadenitis. Jpn J Ophthalmol. 2021;65(4):345-356.
McGrath LA, Gajdatsy MA, Selva D. IgG4-Related Disease: Pathophysiology and Clinical Manifestations in Lacrimal and Salivary Glands. Ocul Surf. 2020;18(3):380-390.
Sato H, Yamamoto K, Abe H, Moriyama H. Long-Term Outcomes of Immunotherapy in IgG4-Related Dacryoadenitis: A Retrospective Cohort Study. Rheumatology. 2019;58(11):2043-2051.
Wang L, Chen R, Liu Q, Zhang Y. Efficacy of Rituximab in IgG4-Related Sialadenitis: Systematic Review and Meta-Analysis. Autoimmun Rev. 2022;21(5):103112.
Medication Comparisons
Compare medications used to treat Igg4 Related Dacryoadenitis And Sialadenitis C0026103. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy