Immunodeficiency 67 C1843256
A genetic immunodeficiency condition that weakens immune defenses and increases vulnerability to various infections.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent severe infections (bacterial and viral)
(immunologic)Autoimmune hemolytic anemia
(hematologic)Lymphoproliferative disease (e.g., lymphoma)
(immunologic)Severe inflammatory bowel disease-like enteropathy
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Regular immunoglobulin infusions provide essential antibodies that the immune system cannot adequately produce. Dosing is individualized based on trough levels and clinical response.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Curative approach that replaces defective immune cells with healthy donor stem cells. Reserved for severe cases not controlled with standard therapy.
Additional treatment options
Antifungal Prophylaxis
Patients with combined immunodeficiencies benefit from prophylactic antifungals to prevent opportunistic fungal infections that can be life-threatening.
medicationInfection Surveillance Protocol
Aggressive monitoring for signs of infection with low threshold for initiating empiric antimicrobial therapy. Regular imaging and laboratory evaluation for occult infections.
monitoringVitamin D Supplementation
Adequate vitamin D levels support immune regulation and bone health in immunodeficient patients. Supplementation addresses deficiency common in housebound patients.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency 67 C1843256?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy