Immunodeficiency Common Variable 1 C3149378
A disorder causing low antibody levels, leading to recurrent infections. It can develop in childhood or adulthood. Treatment involves immunoglobulin replacement and managing infections.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent lower respiratory tract infections
(immunologic)Persistent fatigue
(immunologic)Autoimmune hemolytic anemia
(immunologic)Granulomatous lung disease
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement Therapy
Regular immunoglobulin infusions to provide passive immunity and reduce frequency of infections in this antibody deficiency.
Antibiotic Treatment for Acute Infections
Prompt and aggressive antibiotic therapy for any respiratory or other infections to prevent complications.
Additional treatment options
Pulmonary Rehabilitation
Structured exercise and breathing programs to maintain lung function and improve quality of life.
lifestyleNutritional Support
Balanced nutritional intake with adequate protein and micronutrients to support immune function and prevent muscle wasting.
dietaryAnnual Lung Function and Imaging
Regular pulmonary function testing and imaging to detect and monitor bronchiectasis or other structural lung changes.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency Common Variable 1 C3149378?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Immunodeficiency Common Variable 1 C3149378. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy