Immunodeficiency Common Variable 2 C3150354
A condition where the immune system fails to produce adequate antibodies. Patients experience repeated bacterial infections. Ongoing immunoglobulin therapy is the main treatment approach.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent bacterial sinusitis
(immunologic)Persistent generalized lymphadenopathy
(immunologic)Chronic inflammatory bowel disease-like diarrhea
(immunologic)B-cell lymphoma
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunoglobulin Replacement Therapy
Lifelong immunoglobulin replacement to correct humoral immune deficiency and prevent recurrent infections.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Azithromycin Prophylaxis
Long-term macrolide therapy for its anti-inflammatory and immunomodulatory effects alongside infection prevention.
Additional treatment options
Airway Clearance Techniques
Chest physiotherapy and flutter valve use to help clear secretions and reduce pulmonary exacerbations.
physical_therapyComprehensive Immunological Assessment
Regular monitoring of immunoglobulin levels, specific antibody responses, and lymphocyte subsets.
monitoringPsychological Support and Counseling
Mental health support to address the chronic nature of the condition, anxiety, depression, and quality of life concerns.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency Common Variable 2 C3150354?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy