Immunodeficiency Common Variable 7 C3542922
A genetic immunodeficiency causing reduced antibody levels. It presents with recurrent respiratory and sinus infections. Long-term immunoglobulin therapy helps manage the condition.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent respiratory tract infections
(immunologic)Non-infectious inflammatory disease
(immunologic)Hepatic dysfunction
(immunologic)Lymphoma predisposition
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to replace deficient antibodies. This is the cornerstone of CVID management, typically given every 3-4 weeks to maintain adequate immunoglobulin G levels and prevent recurrent infections.
Antibiotic Prophylaxis
Long-term prophylactic antibiotics such as trimethoprim-sulfamethoxazole or azithromycin may be prescribed to prevent bacterial infections, particularly in patients with recurrent sinopulmonary infections despite immunoglobulin therapy.
Additional treatment options
Regular Immunological Monitoring
Scheduled blood tests to monitor immunoglobulin levels, antibody responses to vaccines, and disease progression. This helps guide treatment adjustments and identify complications such as autoimmunity or granulomatous disease.
monitoringInfection Prevention Strategies
Avoidance of crowded places during peak respiratory seasons, good hand hygiene practices, and prompt medical attention for signs of infection. Patients should stay up-to-date with recommended vaccinations including inactivated vaccines.
lifestyleNutritional Support
Comprehensive nutritional assessment and supplementation as needed, particularly for patients with gastrointestinal complications or malabsorption which can occur in CVID. Vitamin D and calcium supplementation may support bone health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency Common Variable 7 C3542922?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Immunodeficiency Common Variable 7 C3542922. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy