Immunodeficiency Due To A Late Component Of Complement Deficiency C0398765
Deficiency in late complement components needed to form the membrane attack complex. This increases risk for certain bacterial infections, particularly Neisseria. Management includes antibiotic prophylaxis.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Disseminated neisserial infections
Recurrent Neisseria meningitis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gonococcal infection susceptibility
(systemic)Atypical mycobacterial skin infections
(dermatologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibiotic Prophylaxis Regimen
Chronic antibiotic prophylaxis targeting Neisseria species and other encapsulated organisms, which are particularly problematic in terminal complement deficiencies.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Supplementation
Regular immunoglobulin replacement provides essential antibody coverage against encapsulated bacteria, particularly important in C5-C9 deficiencies affecting membrane attack complex formation.
Additional treatment options
Meningococcal Vaccination
Priority vaccination with meningococcal conjugate and serogroup B vaccines due to exceptionally high risk of meningococcal disease in late component deficiencies.
procedureInfection Complication Surveillance
Vigilant monitoring for signs of systemic infection with low threshold for intervention, including periodic laboratory evaluation during wellness.
monitoringStress Reduction and Immune Support
Complementary approaches including stress management, adequate sleep, and mindfulness practices to support overall immune function and reduce infection-triggering factors.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency Due To A Late Component Of Complement Deficiency C0398765?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy