Immunodeficiency With Factor H Anomaly Cn293972
A genetic disorder affecting factor H, a protein that controls complement activity. This leads to complement dysregulation and increased infection risk. Treatment focuses on infection prevention and monitoring.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent upper respiratory tract infections
(immunologic)Persistent fatigue
(immunologic)Autoimmune thrombocytopenia
(immunologic)Opportunistic infection (Pneumocystis pneumonia)
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Eculizumab or Ravulizumab
Complement inhibitor therapy to address the factor H anomaly and prevent complement-mediated tissue damage.
Antibiotic Prophylaxis
Preventive antibiotics to reduce infection risk, particularly against encapsulated bacteria.
Additional treatment options
Complement and Renal Function Monitoring
Regular assessment of complement activity levels, renal function, and markers of hemolysis to evaluate disease control.
monitoringPlasma Exchange
Therapeutic plasma exchange to remove pathogenic factors and replace deficient complement regulatory proteins.
procedureVaccination with Appropriate Vaccines
Completion of recommended vaccinations including pneumococcal, meningococcal, and Haemophilus influenzae vaccines.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Immunodeficiency With Factor H Anomaly Cn293972?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy