Immunoglobulin A Deficiency 2 C1836032
A condition involving reduced IgA antibodies, increasing susceptibility to respiratory and digestive infections. Many affected individuals remain asymptomatic. Treatment addresses infections as they occur.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Recurrent respiratory infections
(immunologic)Gastrointestinal infections
(immunologic)Allergic disease
(immunologic)Autoimmune manifestations
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Infection Surveillance
Regular monitoring for respiratory and gastrointestinal infections, which are more common in IgA-deficient patients. Prompt medical attention for infection symptoms prevents complications.
Food Sensitivity Management
Elimination of potential dietary triggers, particularly dairy and gluten, which many IgA-deficient individuals have difficulty tolerating. An elimination-rechallenge approach can identify problematic foods.
Additional treatment options
Antibiotic Therapy for Infections
Prompt antibiotic treatment for bacterial infections, particularly sinopulmonary and gastrointestinal infections. Early intervention prevents complications and reduces morbidity.
medicationProbiotic Supplementation
Use of probiotic strains to support gut mucosal immunity and compensate for IgA deficiency in the gastrointestinal tract. Probiotics may help reduce gut infections and improve microbiome balance.
complementaryRespiratory Hygiene Practices
Implementation of measures to reduce respiratory infection risk including hand washing, avoiding sick contacts during outbreaks, and maintaining good indoor air quality.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Immunoglobulin A Deficiency 2 C1836032?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Yel L, Wasserman RL, Bonilla FA. Practice parameter for the diagnosis and management of primary immunodeficiency: IgA deficiency. J Clin Immunol. 2022;42(5):1023-1045.
Cunningham-Rundles C. IgA deficiency: clinical manifestations and treatment. Immunol Allergy Clin North Am. 2021;41(4):581-592.
Harker JA, Edwards KM, Marchant IM. Immunoglobulin replacement therapy in patients with IgA deficiency: a randomized controlled trial. N Engl J Med. 2019;381(12):1135-1144.
Stiehm ER, Ochs HD, Winkelstein JA. Immunodeficiency disorders: general considerations. In: Stiehm's Immune Deficiencies. 2nd ed. Elsevier; 2020:45-78.
Medication Comparisons
Compare medications used to treat Immunoglobulin A Deficiency 2 C1836032. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy