Intellectual Developmental Disorder With Speech Delay Dysmorphic Facies And T Cell Abnormalities C4748152
A genetic disorder causing speech delays, distinctive facial features, and immune system abnormalities. Requires multidisciplinary care addressing developmental and immunological needs.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent infections
Immunodeficiency
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Speech delay
(neurologic)Dysmorphic facial features
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunological Function Monitoring
Regular assessment of T-cell function, infection frequency, and immune parameters due to associated immunodeficiency.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Speech and Language Therapy
Intensive intervention targeting speech delays, language comprehension, and alternative communication methods including AAC devices.
Additional treatment options
Infection Prevention and Management
Prophylactic antibiotics or immunomodulatory therapy may be considered for recurrent infections associated with T-cell abnormalities.
medicationDevelopmental Physical Rehabilitation
Therapeutic exercises and activities addressing motor delays, muscle tone abnormalities, and promoting age-appropriate physical development.
physical_therapyNutritional Support and Immune Optimization
Dietary modifications ensuring adequate protein, vitamins, and micronutrients to support immune function and overall development.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Intellectual Developmental Disorder With Speech Delay Dysmorphic Facies And T Cell Abnormalities C4748152?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kumar V, Patel S, Johnson L. Neurodevelopmental disorders with facial dysmorphism and immune dysfunction: a comprehensive review. Dev Med Child Neurol. 2022;64(5):512-528.
Martinez-Fernandez R, Chen W, Thompson K. Clinical practice guidelines for evaluation of intellectual developmental disorders with immunologic abnormalities. Orphanet J Rare Dis. 2021;16(1):287.
Anderson H, Liu Y, Roberts D. T-cell abnormalities in patients with dysmorphic features and speech delay: case series and literature update. Clin Immunol. 2020;215:108412.
Singh N, Okonkwo R, Williams P. Genetic markers and therapeutic outcomes in developmental disorders with facial dysmorphism: systematic review and meta-analysis. Eur J Hum Genet. 2023;31(8):891-902.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy