Intestinal Obstruction In The Newborn Due To Guanylate Cyclase 2c Deficiency C4518781
A rare genetic condition in newborns where the intestines cannot properly move food due to an enzyme deficiency. Requires surgical intervention and specialized nutritional support.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bilious vomiting
Abdominal distension
Meconium ileus
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Failure to pass meconium
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Surgical Correction of Obstruction
Emergency surgical intervention to relieve the intestinal obstruction, which may include resection of affected bowel segments or bypass procedures depending on the extent and location of obstruction.
Nasogastric Decompression
Placement of nasogastric tube to decompress the stomach and intestines, relieve pressure, and prevent aspiration. Essential pre-operative and post-operative management component.
Additional treatment options
Parenteral Nutrition Support
Intravenous nutrition to maintain adequate caloric intake and hydration when enteral feeding is not possible due to obstruction. Provides essential nutrients for growth and development in newborns.
dietaryPost-operative Gastrointestinal Monitoring
Close monitoring of bowel function, stoma output if applicable, and nutritional status following surgical intervention. Includes assessment for complications such as anastomotic leak or infection.
monitoringProbiotic Supplementation
Administration of beneficial bacteria to support gut microbiome recovery following surgical intervention and antibiotic therapy. May help restore normal intestinal function over time.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Intestinal Obstruction In The Newborn Due To Guanylate Cyclase 2c Deficiency C4518781?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy