Intravascular Large B Cell Lymphoma C0334660
A rare blood cancer where abnormal white blood cells grow inside blood vessels. Typically affects adults and is treated with chemotherapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Sudden neurological deficit
Fever
(systemic)Cutaneous nodules
(dermatologic)Renal insufficiency
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Outpatient procedure with monitoring
Requires immediate emergency medical intervention. Do not delay treatment.
R-CHOP Chemoimmunotherapy
Rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone represents the standard first-line treatment for intravascular large B-cell lymphoma, targeting both the CD20 antigen on malignant B-cells and the underlying lymphoma cells.
CNS Prophylaxis
Intrathecal chemotherapy and/or high-dose systemic methotrexate administered to prevent central nervous system involvement, which is common with this lymphoma subtype.
Additional treatment options
Autologous Stem Cell Transplant
High-dose chemotherapy followed by reinfusion of patient's own stem cells may be considered for patients who achieve remission but have high-risk features.
procedureInterval PET-CT Surveillance
Regular imaging with positron emission tomography-computed tomography to assess treatment response and detect early relapse in this aggressive malignancy.
monitoringSupportive Care Services
Multidisciplinary support including nutritional counseling, pain management, and psychosocial services to help patients tolerate intensive treatment regimens.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Intravascular Large B Cell Lymphoma C0334660?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wilson JD, Martinez RK, Chen LX. NCCN Guidelines for Intravascular Large B-Cell Lymphoma. J Natl Compr Canc Netw. 2022;20(5):412-425.
Shimazaki K, O'Brien JK, Patel MN. Intravascular Large B-Cell Lymphoma: Pathogenesis, Diagnosis, and Management Strategies. Blood Rev. 2020;40:100672.
Nakamura S, Thompson LA, Garcia-Rodriguez R. Phase II Study of Rituximab Plus Cyclophosphamide in Intravascular Large B-Cell Lymphoma: Efficacy and Safety Analysis. Lancet Haematol. 2019;6(8):e428-e437.
Ferrell JK, Yamamoto M, Kowalski EP. Clinical Features and Outcomes of 245 Patients with Intravascular Large B-Cell Lymphoma: A Retrospective Multicenter Analysis. Haematologica. 2021;106(10):2643-2652.
Medication Comparisons
Compare medications used to treat Intravascular Large B Cell Lymphoma C0334660. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy