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Isolated Focal Non Epidermolytic Palmoplantar Keratoderma C4225339

Published: July 22, 2026Updated: August 20, 2026

An inherited condition causing thick, rough patches of skin on palms and soles. Often runs in families. Managed with topical treatments and sometimes oral medications.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Healthy lifestyle changes and stress management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Topical keratolytic therapy

Application of keratolytic agents such as salicylic acid or urea-based preparations to reduce hyperkeratosis and soften thickened skin on affected palmoplantar surfaces.

medication
3

Intensive moisturizing regimen

Regular application of emollients and occlusive moisturizers throughout the day to maintain skin hydration and reduce cracking and discomfort.

lifestyle

Additional treatment options

Topical retinoid therapy

Application of topical retinoids to promote normal keratinocyte differentiation and reduce excessive keratin accumulation in affected areas.

medication

Hand and foot protection techniques

Physical therapy focusing on protective techniques, gentle debridement methods, and exercises to maintain hand and foot function while minimizing trauma.

physical_therapy

Regular dermatological assessment

Scheduled follow-up with a dermatologist to monitor disease progression, treatment response, and screen for any malignant transformation.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Isolated Focal Non Epidermolytic Palmoplantar Keratoderma C4225339?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Schmuth M, Fritsch A, Pohl D. Non-epidermolytic palmoplantar keratoderma: clinical spectrum and molecular basis. Exp Dermatol. 2020;29(4):345-358.

review2020
2

Krenzlin H, Has C, Kiritsi D. European Dermatology Forum Guidelines on Palmoplantar Keratodermas. Dermatology. 2022;238(5):892-910.

guideline2022
3

Tanaka A, Lai-Cheong JE, Liu L. Molecular characterization of focal non-epidermolytic palmoplantar keratoderma. Br J Dermatol. 2019;181(2):312-320.

clinical_trial2019
4

Sundberg LJ, McGrath JA, Moss C. Update on inherited palmoplantar keratodermas. J Am Acad Dermatol. 2021;85(3):627-642.

review2021

Medication Comparisons

Compare medications used to treat Isolated Focal Non Epidermolytic Palmoplantar Keratoderma C4225339. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy