Japanese Spotted Fever C2108396
A tick-borne rickettsial disease found in Japan and East Asia, causing fever, rash, and skin lesions. Early antibiotic treatment leads to recovery in most cases.
Key facts at a glance
- ICD-10
- B99.9
- ICD-11
- 1A00.0
- Body system
- infectious
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Fever or malaise
(infectious)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
High fever
(general)Maculopapular rash
(skin)Eschar at tick bite site
(skin)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antimicrobial or antiviral therapy
Active treatment with regular monitoring by a healthcare provider is recommended.
Doxycycline antibiotic therapy
Prompt initiation of doxycycline as first-line antimicrobial therapy to target Rickettsia japonica, which is highly responsive to tetracycline-class antibiotics when given early.
Supportive care and fever management
Supportive treatment including antipyretics for fever control, adequate hydration, and monitoring for complications such as organ dysfunction or disseminated disease.
Additional treatment options
Tick exposure prevention
Public health measures and personal precautions to prevent tick bites including wearing protective clothing, using tick repellents, and performing regular body checks after outdoor activities.
lifestyleCardiac and hepatic monitoring
Monitoring for systemic complications including cardiac involvement, hepatic dysfunction, and hematologic abnormalities that may develop during rickettsial infection.
monitoringDiagnostic eschar biopsy
Skin biopsy of the characteristic eschar lesion to confirm diagnosis through histopathology and molecular testing, guiding treatment duration and confirming clinical suspicion.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Japanese Spotted Fever C2108396?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy