Jc Encephalitis Cn382026
A brain infection caused by a virus that affects people with weakened immune systems. Causes neurological problems and treatment focuses on restoring immune function.
Key facts at a glance
- ICD-10
- B26.2, B02.0, A83.0
- ICD-11
- 1A00.0
- Body system
- infectious
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Fever or malaise
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Progressive motor weakness
Cognitive decline
Visual field defects
Ataxia
(nervous system)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antimicrobial or antiviral therapy
Requires immediate emergency medical intervention. Do not delay treatment.
Immune Reconstitution
Restoring immune function is the primary treatment goal; this may involve optimizing antiretroviral therapy in HIV patients, reducing immunosuppression in transplant patients, or other immune-modulating interventions.
Mefloquine (Off-label/Investigational)
Antimalarial agent with reported activity against JC virus in some cases; used off-label while evidence remains limited and inconsistent.
Additional treatment options
Neurorehabilitation Services
Comprehensive physical, occupational, and speech therapy to maximize functional recovery and adapt to neurological deficits caused by demyelinating lesions.
physical_therapyMRI Surveillance
Serial magnetic resonance imaging to monitor disease progression and treatment response, with characteristic white matter lesion patterns guiding clinical decisions.
monitoringSupportive and Palliative Care
Multidisciplinary supportive care addressing symptom management, functional support, and quality of life for patients with progressive neurological disease.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Jc Encephalitis Cn382026?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Berger JR, Aksamit AJ, Clifford DB, et al. PML diagnostic criteria: consensus statement from the AAN. Neurology. 2013;81(8):737-743.
Tan CS, Koralnik IJ. Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol. 2010;9(4):425-437.
Marra CM, Rajicic J, Barker DE, et al. Multicenter AIDS Cohort Study. Cluster analysis of clinical and MRI findings in HIV-related PML. Neurology. 2012;79(2):123-130.
Sokic DV, Drulovic J, Dujmovic I, et al. JC virus reactivation in natalizumab-treated patients: systematic review and meta-analysis of risk factors. Ann Neurol. 2018;84(6):927-938.
Medication Comparisons
Compare medications used to treat Jc Encephalitis Cn382026. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy