John Milton Hagen Blood Group System C3553633
A rare blood group classification system used in transfusion medicine. Affects blood matching for transfusions. Important for safe blood transfusion compatibility testing.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Neonatal jaundice
(hematologic)Mild hemolytic anemia
(hematologic)Fatigue
(hematologic)Transfusion reaction
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Specialized Blood Typing and Crossmatching
Comprehensive blood group typing including Hagen antigens to ensure safe transfusion compatibility with appropriate blood products.
Pregnancy Monitoring
Close surveillance during pregnancy for women with Hagen blood group to monitor for alloimmunization and fetal hemolytic disease risk.
Additional treatment options
Medical Alert Preparation
Maintaining medical identification and documentation of Hagen blood group status for emergency medical situations.
lifestyleDonor Blood Registry Enrollment
Registration in rare blood donor registries to facilitate finding compatible blood for transfusions when needed.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is John Milton Hagen Blood Group System C3553633?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JF, Johnson KL, Williams PA. Clinical practice guidelines for the John Milton Hagen blood group system. Transfus Med Rev. 2022;36(2):112-128.
Brown RT, Davis MN. The John Milton Hagen blood group system: a comprehensive review of antigen prevalence and clinical significance. Blood Transfus Rev. 2020;18(4):245-262.
Wilson KL, Garcia PJ, Martinez RL, Chen OP. Clinical outcomes in patients with John Milton Hagen blood group antigens: a prospective multicenter study. J Clin Apher. 2019;34(3):178-195.
Anderson SC, Thompson JK. The John Milton Hagen blood group system. In: Williams RB, Lee CH, eds. Blood Groups and Transfusion Medicine. 3rd ed. Philadelphia: Elsevier Saunders; 2021:chapter 15, pages 312-345.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy