Juvenile Polyposis Syndrome C0345893
A genetic condition causing multiple benign polyps to grow in the digestive tract, increasing cancer risk. Requires lifelong monitoring and may need polyp removal.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rectal bleeding
Intussusception
Abdominal pain or nausea
(gastrointestinal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Abdominal pain
(gastrointestinal)Anemia
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endoscopic Surveillance and Polypectomy
Regular upper and lower endoscopy with removal of polyps to prevent bleeding, anemia, and reduce malignancy risk. Polyps are removed as they are identified during surveillance.
GI disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Colectomy
Surgical removal of the colon when polyp burden becomes unmanageable endoscopically or when high-grade dysplasia is detected. May involve total or subtotal colectomy with ileorectal anastomosis.
Additional treatment options
Proton Pump Inhibitor Therapy
Acid suppression to reduce upper GI bleeding from gastric polyps and improve tolerability of any iron supplementation therapy for associated anemia.
medicationIron and Nutritional Supplementation
Targeted replacement of iron, B12, and folate as needed given chronic blood loss. Dietary counseling to maximize iron absorption and overall nutritional status.
dietaryGenetic Testing and Family Screening
Germline SMAD4 mutation testing for the patient and cascade testing of family members. Guides surveillance protocols and reproductive counseling.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Juvenile Polyposis Syndrome C0345893?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy