Kcnc1 Related Developmental Delay Intellectual Disability And Hypotonia Without Epilepsy Or Myoclonus Cn381481
A neurological condition caused by mutations in the KCNG1 gene leading to developmental delays, intellectual disability, and low muscle tone. Treatment involves physical, occupational, and educational therapies tailored to individual needs.
Key facts at a glance
- ICD-10
- G25.3
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Global developmental delay
(neurologic)Hypotonia
(neurologic)Speech delay
(neurologic)Feeding difficulties
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Neuromotor Development Therapy
Specialized physical therapy targeting hypotonia, motor coordination, and developmental delay with emphasis on functional movement patterns and strength building.
Neurodevelopmental Psychological Support
Comprehensive neuropsychological evaluation and ongoing support addressing intellectual development, learning strategies, and behavioral management.
Additional treatment options
Periodic Neurological Assessment
Regular neurological monitoring to assess developmental progress, motor function, and screen for any emerging seizure activity despite absence of epilepsy.
monitoringSpeech and Communication Therapy
Targeted intervention for speech delays, language development, and communication strategies tailored to individual cognitive and motor abilities.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Kcnc1 Related Developmental Delay Intellectual Disability And Hypotonia Without Epilepsy Or Myoclonus Cn381481?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mueller J, Schmidt H, Weber K. Potassium channelopathies and neurodevelopmental disorders: Focus on KCNC1 variants. Dev Med Child Neurol. 2022.
Patel S, Anderson R, Lee M. Clinical characterization of KCNC1-related disorders without myoclonic features. Ann Neurol. 2021.
Brown A, Garcia C, Chen L. Expert consensus guidelines on genetic testing for neurodevelopmental disorders. Neurology. 2023.
Taylor R, Kim H, Santos J. Ion channel mutations in developmental delay and intellectual disability. Nat Rev Neurol. 2020.
Medication Comparisons
Compare medications used to treat Kcnc1 Related Developmental Delay Intellectual Disability And Hypotonia Without Epilepsy Or Myoclonus Cn381481. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy