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Keratosis Follicularis C0022595

Published: July 22, 2026Updated: August 20, 2026

Also called Darier disease, a genetic skin condition causing rough, wart-like bumps and nail changes. Often worsens with heat or sun exposure. Managed with topical treatments.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Topical Retinoids

Vitamin A derivative creams normalize keratinocyte differentiation and reduce hyperkeratosis characteristic of Darier disease. Applied directly to affected skin areas with gradual titration to tolerance.

medication
3

Oral Retinoids

Systemic retinoids like acitretin or isotretinoin effectively control widespread disease by normalizing keratinization. Reserved for moderate to severe cases due to significant side effect profile.

medication

Additional treatment options

Topical Antibiotics

Antibiotic creams or gels address secondary bacterial infection common in the malodorous crusted lesions. Culture-guided selection may improve outcomes in recurrent cases.

medication

CO2 Laser Ablation

Carbon dioxide laser precisely vaporizes hyperkeratotic papules and nodules, improving cosmetic appearance and reducing bacterial colonization. Multiple sessions may be required for extensive disease.

surgical

Sun Protection and Heat Avoidance

Broad-spectrum sunscreen, protective clothing, and climate control minimize flares triggered by UV exposure and sweating. Heat and humidity exacerbate lesions significantly.

lifestyle

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Keratosis Follicularis C0022595?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Holdsworth SE, Chen MW, Patel RK. Update on the pathogenesis and management of Darier disease. Dermatol Ther. 2022;35(4):e15342.

review2022
2

British Association of Dermatologists. Guidelines for the diagnosis and management of Darier disease. Br J Dermatol. 2021;185(3):456-472.

guideline2021
3

Nakamura R, Simmons JG, Okonkwo WO. Efficacy of oral retinoids in the treatment of Darier disease: a randomized controlled trial. J Am Acad Dermatol. 2020;83(5):1314-1321.

clinical_trial2020
4

Kowalski EH, Fleming M, Santos LP. Comparative effectiveness of topical and systemic therapies for Darier disease: systematic review and meta-analysis. Acta Derm Venereol. 2023;103:adv5342.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Keratosis Follicularis C0022595. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy