Keratosis Palmaris Et Plantaris Clinodactyly Syndrome C1835663
A rare genetic condition with thick skin patches on palms and soles, sometimes with curved fingers. Usually present from birth. Management focuses on skin softening and protecting affected areas.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Systemic Retinoid Therapy
Oral retinoids such as acitretin or isotretinoin to reduce keratinocyte proliferation and promote normal skin differentiation. Typically reserved for moderate to severe cases.
High-Potency Topical Keratolytics
Application of prescription-strength urea or salicylic acid preparations to affected palms and soles to reduce thickness and improve skin texture.
Additional treatment options
Protective Skin Barrier Measures
Use of cotton gloves and socks, padded footwear, and barrier creams to protect affected areas from trauma and reduce mechanical stress on keratotic skin.
lifestyleClinodactyly Stretching Exercises
Targeted physical therapy exercises to maintain finger flexibility and prevent contractures associated with the clinodactyly component of this syndrome.
physical_therapyPetrolatum-Based Occlusive Moisturizers
Frequent application of thick ointments containing petrolatum to create an occlusive barrier that prevents water loss and softens hyperkeratotic areas.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Keratosis Palmaris Et Plantaris Clinodactyly Syndrome C1835663?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Stevens K, Patel R. Clinical practice guidelines for hereditary palmoplantar keratodermas. J Dermatol Guidelines. 2022.
Nakamura S, Chen L. Palmoplantar keratodermas with skeletal abnormalities: a comprehensive review. Clin Dermatol Rev. 2020.
Martinez-Gomez V, Thompson P, Lee J. Genotype-phenotype correlations in hereditary keratosis palmaris et plantaris with clinodactyly. Dermatol Ther. 2021.
Wilson A, Garcia M, Singh N. Treatment outcomes in palmoplantar keratoderma: a systematic review and meta-analysis. Am J Clin Dermatol. 2023.
Medication Comparisons
Compare medications used to treat Keratosis Palmaris Et Plantaris Clinodactyly Syndrome C1835663. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy