Kidney Papillary Necrosis C0022667
Kidney papillary necrosis is death of kidney tissue due to poor blood supply. It often occurs with diabetes, sickle cell disease, or certain medications. Treatment focuses on addressing the underlying cause.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hematuria
Flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Fever
(systemic)Nausea and vomiting
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Treatment of Underlying Cause
Identification and treatment of the underlying etiology is essential. This may include appropriate antibiotics for infection, optimization of diabetes control, or management of analgesic overuse. Addressing the root cause prevents further renal damage.
Hydration Management
Aggressive fluid intake to maintain adequate urine output and prevent further ischemic damage to the renal papillae. In patients with sickle cell disease, maintaining euvolemia is particularly critical.
Additional treatment options
Pain Management
Appropriate analgesia for flank pain or renal colic associated with papillary necrosis. NSAIDs may be used cautiously, particularly in patients without significant renal impairment.
medicationRenal Function Monitoring
Regular assessment of kidney function through serum creatinine, eGFR, and urinalysis to detect progression of renal impairment. Serial imaging may help track structural changes.
monitoringSurgical Intervention
Reserved for complications such as obstruction, severe hemorrhage, or when necrotic tissue becomes infected. May include ureteral stenting, percutaneous drainage, or partial nephrectomy in select cases.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Kidney Papillary Necrosis C0022667?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Kidney Papillary Necrosis C0022667. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy