Kikuchi Fujimoto Disease C0398367
A rare inflammatory condition that primarily affects the lymph nodes, commonly in young adults. Symptoms may include swollen lymph nodes, fever, and fatigue. Most people recover with supportive care, though follow-up is important.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cervical lymphadenopathy
(immunologic)Generalized symptoms
(immunologic)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Fever
(immunologic)Night sweats
(immunologic)Skin rash
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Clinical observation
Kikuchi-Fujimoto disease is typically self-limiting with most cases resolving spontaneously within 1-6 months. Regular follow-up to monitor symptom progression and resolution.
Lifestyle modification and dietary intervention
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Additional treatment options
NSAIDs for symptom control
Non-steroidal anti-inflammatory medications provide relief from fever, pain, and lymphadenopathy while the disease runs its natural course.
medicationCorticosteroid therapy
Short-course oral corticosteroids for severe or prolonged cases with significant symptoms, persistent lymphadenopathy, or constitutional symptoms not responding to NSAIDs.
medicationRest and supportive care
Adequate rest, hydration, and nutrition support the immune system during recovery. Light activity as tolerated promotes circulation and general well-being.
lifestyleAnxiety reduction and education
Patient and family education about the benign, self-limiting nature of the disease helps reduce anxiety. Support groups or counseling may be beneficial for those with prolonged symptoms.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Kikuchi Fujimoto Disease C0398367?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bosch X, Guilabert A, Miquel R, Campo E. Enigmatic Kikuchi-Fujimoto disease: a comprehensive review. Am J Clin Pathol. 2014.
Perry AM, Choi SM. Diagnosis and management of Kikuchi-Fujimoto disease: consensus statement from the Society of Hematopathology. Hum Pathol. 2018.
Lin YW, Hsu SM, Chen CC. Kikuchi-Fujimoto disease: clinical features and outcomes in 127 patients. Medicine (Baltimore). 2019.
Sabel M, Roos JC, Lamprecht J. Kikuchi-Fujimoto disease: a systematic review of the global literature. Autoimmun Rev. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy