Kimura Disease C0033838
A chronic inflammatory disorder causing painless nodules in skin and lymph nodes, most often in young to middle-aged males. It may also affect internal organs. Treatment may include medications to manage symptoms and reduce inflammation.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Subcutaneous nodules
(immunologic)Eosinophilia
(immunologic)Pruritus
(immunologic)Lymphadenopathy
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Corticosteroid therapy
Systemic corticosteroids are used to reduce inflammation and suppress the immune-mediated inflammatory response characteristic of Kimura disease. Treatment typically begins with higher doses followed by gradual tapering over several months.
Surgical excision
Complete surgical removal of lesions is often performed for accessible nodules, particularly when cosmetic concerns exist or when lesions cause functional impairment.
Additional treatment options
Immunosuppressive agents
Alternative immunosuppressants such as cyclosporine or mycophenolate may be used when steroids are contraindicated or as steroid-sparing agents for long-term management.
medicationRadiation therapy
Low-dose radiation therapy may be considered for recurrent or multiple lesions that are not amenable to surgery, particularly in the head and neck region.
procedureWatchful waiting with regular follow-up
Asymptomatic patients with stable lesions may be monitored with periodic clinical examination and imaging to assess for any changes in size or number of lesions.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Kimura Disease C0033838?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen W, Liu S, Yang J. Kimura Disease: Clinical Features, Diagnosis, and Treatment Advances. Dermatol Ther. 2022.
National Organization for Rare Disorders. Kimura Disease: Consensus Clinical Practice Guidelines. Orphanet J Rare Dis. 2021.
Zhang H, Kim R, Patel M, Lee S. Efficacy of Sirolimus in Refractory Kimura Disease: A Prospective Clinical Trial. J Am Acad Dermatol. 2023.
Wang Y, Huang Q, Li N, Liu Z. Treatment Outcomes of Kimura Disease: A Systematic Review and Meta-Analysis. Int J Dermatol. 2020.
Medication Comparisons
Compare medications used to treat Kimura Disease C0033838. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy