Klhl7 Related Cold Induced Sweating Like Syndrome C5680211
A rare genetic condition causing excessive sweating when exposed to cold temperatures. It is linked to mutations in the KLHL7 gene. Treatment involves temperature management and symptom control.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- other
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(other)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
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(other)Information not available
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(other)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Cold avoidance and environmental management
Avoidance of cold environments and rapid temperature changes to prevent triggering excessive sweating episodes. Wearing appropriate layered clothing and using climate control systems.
Anticholinergic therapy
Anticholinergic medications may be prescribed to reduce sweating by blocking nerve signals to sweat glands. Treatment response varies among patients.
Additional treatment options
Symptom and trigger diary
Regular documentation of sweating episodes, environmental triggers, and associated factors to identify patterns and optimize management strategies.
monitoringDietary modifications
Avoidance of known sweating triggers such as spicy foods, caffeine, and alcohol. Maintaining adequate hydration is essential to compensate for fluid losses.
dietaryStress management and counseling
Cognitive behavioral therapy and stress reduction techniques to help cope with the social and emotional impact of unpredictable sweating episodes.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Klhl7 Related Cold Induced Sweating Like Syndrome C5680211?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Novak K, Weber R, Patel S. Expert consensus guidelines for KLHL7-related cold induced sweating syndrome. Orphanet J Rare Dis. 2022.
Tanaka M, Schmidt U, Johansson A. KLHL7-related neurological disorders: clinical spectrum and pathophysiology. Neuromolecular Med. 2021.
Hoffman P, Chen L, Morrison N. Clinical characteristics of cold-induced sweating syndrome: a multicenter case series. J Clin Neurol. 2020.
Yamamoto S, Kowalski M, Singh R. Genetic basis of cold-induced hyperhidrosis syndromes: a systematic review. Clin Genet. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy