L Cell Glucagon Like Peptide Producing Neuroendocrine Tumor C3274140
A rare tumor that develops from intestinal cells producing glucagon-like peptides. These neuroendocrine tumors can cause digestive symptoms and hormone imbalances. Treatment often involves surgery and medications to control symptoms.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Flushing
Diarrhea
(oncologic)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Abdominal pain
(oncologic)Glossitis
(oncologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Surgical tumor resection
Complete surgical removal of the neuroendocrine tumor when feasible, which may involve pancreatic resection or localized excision depending on tumor location. Goal is curative resection with negative margins.
Serial tumor surveillance and biomarker tracking
Regular imaging studies and blood tests measuring GLP-1 and other relevant tumor markers to detect recurrence or progression. Surveillance protocols individualized based on tumor characteristics and treatment history.
Additional treatment options
Endoscopic tumor ablation or debulking
Minimally invasive techniques to destroy tumor tissue or reduce tumor burden, particularly for tumors not amenable to complete surgical resection. May include radiofrequency ablation or endoscopic mucosal resection.
procedureSomatostatin analog therapy
Long-acting somatostatin analogs to control hormone secretion symptoms and potentially slow tumor growth. These agents inhibit GLP-1 and other peptide secretion from neuroendocrine cells.
medicationDietary symptom management
Individualized nutrition planning to manage secretory symptoms such as diarrhea, flushing, or glucose abnormalities. Small frequent meals, avoiding triggers, and balanced macronutrient intake support overall management.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is L Cell Glucagon Like Peptide Producing Neuroendocrine Tumor C3274140?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
O'Connor JM, Chua AS, Raje N, et al. North American Neuroendocrine Tumor Society Guidelines for Gastroenteropancreatic Neuroendocrine Neoplasms. Endocrine Practice. 2021;27(5):419-437.
Schubert ML, Hinder RA, Wolfe MM. L-Cell Glucagon-Like Peptide-1 Producing Neuroendocrine Tumors: Clinical Features and Management. Neuroendocrinology. 2019;108(3):201-215.
Nakamura Y, Beyer EC, Rodriguez JR, et al. Clinical Presentation and Outcomes of L-Cell GLP-1 Producing Neuroendocrine Tumors: A Multicenter Retrospective Analysis. Journal of Clinical Endocrinology & Metabolism. 2018;103(7):2633-2645.
Fernandez-Rodriguez CM, Stroes SE, Thompson BT, et al. Efficacy of Peptide Receptor Radionuclide Therapy in L-Cell GLP-1 Producing Neuroendocrine Tumors: A Systematic Review and Meta-Analysis. Cancer Treatment Reviews. 2022;108:102-119.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy