Leber Congenital Amaurosis 9 C1837873
Leber Congenital Amaurosis 9 is a rare inherited condition causing severe vision impairment from infancy. It damages the retina, the light-sensitive part of the eye. Researchers are studying gene therapy as a potential treatment approach.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Profound vision loss
Generalized symptoms
(ophthalmologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Nystagmus
(ophthalmologic)Photophobia
(ophthalmologic)Keratoconus
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
CEP290 gene therapy (when eligible)
For LCA-9 associated with CEP290 mutations, emerging antisense oligonucleotide therapies and gene editing approaches are being investigated in clinical trials.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Kidney function screening
Regular monitoring for renal involvement associated with LCA-9 (Joubert syndrome spectrum), including ultrasound and renal function tests.
Additional treatment options
Environmental modifications
Home and school adaptations including improved lighting, contrast enhancement, and safety modifications to maximize functional vision and prevent accidents.
lifestyleSensory enrichment therapy
Multisensory stimulation programs combining auditory, tactile, and olfactory experiences to support neural development and enhance sensory processing.
complementaryFamily support and education
Comprehensive family education about LCA-9 prognosis, genetic implications, and available resources, along with support for caregiver well-being.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Leber Congenital Amaurosis 9 C1837873?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Leber Congenital Amaurosis 9 C1837873. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy