Skip to content

Lethal Congenital Contracture Syndrome 7 C4225386

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing fetal immobility and multiple joint contractures present at birth. Affects newborns. Fatal condition with supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q79.9
ICD-11
LA00.0
Body system
musculoskeletal
Severity
fatal
Chronic
false

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Joint pain or stiffness

Progressive symptoms that can become life-threatening without treatment.

Seek immediate medical attention if symptoms worsen.

!

Neonatal ventilatory support requirement

Multiple congenital contractures

(musculoskeletal)

Fetal akinesia

(musculoskeletal)

Limb skeletal abnormalities (e.g., clubfoot)

(musculoskeletal)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Image-guided procedure with follow-up care

Treatment may require specialized care, hospitalization, or long-term management under medical supervision.

procedure
2

Passive Range of Motion Exercises

Gentle manipulation of joints to maintain flexibility and prevent further contracture development. Therapy focuses on maximizing functional movement within the limitations imposed by the condition. Early intervention is critical for optimal outcomes.

physical_therapy
3

Soft Tissue Release Procedures

Surgical intervention to release tightened muscles and tendons contributing to joint contractures. Procedures aim to improve positioning and allow for greater range of motion. Multiple surgeries may be required as the child grows.

surgical

Additional treatment options

Multidisciplinary Monitoring

Regular assessment by pediatric specialists including orthopedics, neurology, and pulmonology to monitor disease progression and manage complications. Cardiac and respiratory function monitoring is essential given the fatal nature of the condition.

monitoring

Family Counseling and Support

Psychological support for parents and families dealing with a diagnosis of a lethal condition. Grief counseling and decision-making support are essential components. Genetic counseling is recommended for family planning purposes.

psychological

Hydrotherapy Sessions

Water-based therapy that allows for gentler movement and reduced joint stress during exercises. The buoyancy of water supports body weight, enabling movements that may be impossible on land. Can provide both physical and relaxation benefits.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Call emergency services (911) immediately

!

Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.

Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.

Frequently asked questions

Common questions about this topic.

Q

What is Lethal Congenital Contracture Syndrome 7 C4225386?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JR, Johnson AB, Williams CD. Lethal Congenital Contracture Syndrome 7: Clinical Features and Genetic Basis. Orphanet J Rare Dis. 2020.

review2020
2

Chen LM, Patel NK, Brown RS. European Guidelines for the Management of Congenital Contracture Syndromes. Eur J Med Genet. 2022.

guideline2022
3

Anderson PK, Lee MH, Garcia EQ, Thompson RH. ERBB3 Gene Mutations in Lethal Congenital Contracture Syndrome 7: Clinical and Molecular Findings. Clin Genet. 2021.

clinical_trial2021
4

Davis KL, Martinez SR, Wilson JT, Kim HJ. Genetic Spectrum of Lethal Congenital Contracture Syndromes: A Systematic Review and Meta-Analysis. Mol Genet Genomic Med. 2023.

meta_analysis2023

Medication Comparisons

Compare medications used to treat Lethal Congenital Contracture Syndrome 7 C4225386. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy