Leukocyte Adhesion Deficiency 1 C0398738
A rare inherited immune disorder where white blood cells cannot properly reach infection sites. Patients experience recurrent severe infections from infancy. Treatment involves aggressive infection management and potentially bone marrow transplant.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent bacterial infections
Delayed umbilical cord separation
(immunologic)Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe early-onset periodontitis
(immunologic)Impaired wound healing
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation (HSCT)
Potentially curative treatment that replaces defective immune cells with healthy donor stem cells. Requires careful donor matching and immunosuppressive conditioning regimen before transplantation.
Aggressive Antibiotic Prophylaxis
Long-term prophylactic antibiotics to prevent bacterial infections that patients with LAD-1 cannot effectively combat due to impaired neutrophil migration. Typically includes coverage for common gram-positive and gram-negative organisms.
Additional treatment options
Infection Surveillance Protocol
Regular monitoring for early signs of infection with low threshold for intervention. Includes periodic laboratory evaluation of inflammatory markers and immune function parameters.
monitoringInfection Prevention Measures
Implementation of rigorous hygiene practices including handwashing, avoiding contact with sick individuals, and maintaining clean living environments to minimize exposure to pathogens.
lifestyleNutritional Support
Optimized nutrition with adequate calories and protein to support immune function and overall growth. May include vitamin and mineral supplementation as indicated by nutritional assessments.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Leukocyte Adhesion Deficiency 1 C0398738?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Leukocyte Adhesion Deficiency 1 C0398738. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy