Leukocyte Adhesion Deficiency 3 C2748536
A rare immune deficiency causing white blood cells to malfunction, leading to severe recurrent infections and poor wound healing. It requires careful infection management and sometimes bone marrow transplant as a potential cure.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent infections
Bleeding tendency
Peripheral necrosis
Delayed umbilical cord separation
(immunologic)Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hematopoietic Stem Cell Transplantation (HSCT)
Definitive curative approach replacing defective hematopoietic cells. Unlike LAD-1, LAD-3 also requires addressing the platelet integrin dysfunction component through the transplant.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Hemostatic Management
Use of antifibrinolytic agents such as tranexamic acid to stabilize clots once formed, compensating for the platelet integrin dysfunction that prevents proper platelet aggregation and clot stabilization.
Additional treatment options
Prophylactic Antibiotic Regimen
Continuous antibiotic prophylaxis to prevent recurrent bacterial infections characteristic of the immune dysfunction component of LAD-3.
medicationPlatelet Transfusion Support
Transfusions of platelet concentrates to manage acute bleeding episodes or as perioperative support. Requires careful blood typing and antibody screening.
procedureComprehensive Bleeding and Infection Monitoring
Dual surveillance system tracking both bleeding manifestations and infection susceptibility, given the dual pathophysiology of LAD-3 affecting both immune and hemostatic systems.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Leukocyte Adhesion Deficiency 3 C2748536?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy