Leukoencephalopathy With Vanishing White Matter 5 C5779973
A genetic disorder causing progressive damage to brain white matter that eventually disappears on imaging. It mainly affects children and leads to neurological deterioration. Management includes supportive care and avoiding factors that worsen the condition.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Loss of motor function
(neurologic)Dysarthria
(neurologic)Urinary incontinence
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Regular neurological monitoring
Comprehensive neurological examinations and periodic brain MRI to track disease progression and white matter changes. Early detection of deterioration allows for timely supportive interventions.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Seizure management
Anticonvulsant medications to control seizure activity when present. Selection based on seizure type and patient tolerability with regular monitoring for efficacy and side effects.
Additional treatment options
Stress and infection avoidance
Limiting physical exertion, emotional stress, and exposure to infections which may trigger acute deteriorations. Creating a supportive home environment with appropriate activity modifications.
lifestyleMotor function support
Physical therapy focused on maintaining mobility, balance, and preventing contractures. Therapy intensity adjusted based on patient's current functional level and disease stage.
physical_therapySupportive and palliative care
Multidisciplinary supportive care addressing quality of life, symptom management, and family support. May include occupational therapy, speech therapy, and nutritional support as needed.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Leukoencephalopathy With Vanishing White Matter 5 C5779973?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy