Liddle Syndrome 3 C4748292
A rare inherited condition causing high blood pressure through abnormal kidney function. Similar to other Liddle syndromes, it responds to specific medications that block sodium channels.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Hypokalemia
(metabolic)Metabolic alkalosis
(metabolic)Cardiac arrhythmia
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Sodium Restriction
Strict dietary sodium restriction to reduce fluid retention and blood pressure elevation caused by excessive sodium reabsorption in the kidney tubules.
Potassium-Sparing Diuretics
Medications such as amiloride or triamterene that block epithelial sodium channels, counteracting the genetic defect in Liddle syndrome and reducing hypertension.
Additional treatment options
High-Potassium Diet
Increased dietary potassium intake through fruits and vegetables to counteract hypokalemia and support blood pressure regulation.
dietaryBlood Pressure and Electrolyte Monitoring
Regular home blood pressure monitoring and periodic serum electrolyte panels to assess treatment efficacy and adjust therapy.
monitoringStress Management
Relaxation techniques including meditation and breathing exercises to help manage stress-related blood pressure fluctuations.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Liddle Syndrome 3 C4748292?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RM, Patel SN, Chen KL. International Society of Hypertension guidelines on genetic forms of hypertension. J Clin Hypertens. 2022.
Williams TF, Garcia MO, Thompson HD. Monogenic forms of hypertension: Liddle syndrome and beyond. Curr Hypertens Rep. 2020.
Anderson PJ, Brown SB, Martinez LR. Clinical presentation and genetic analysis of Liddle syndrome variant 3. Hypertension. 2019.
Davis LM, Wilson CC, Taylor AH. Diagnosis and management of secondary hypertension due to ENaC mutations: systematic review. Am J Nephrol. 2021.
Medication Comparisons
Compare medications used to treat Liddle Syndrome 3 C4748292. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy