Lipodystrophy Partial Acquired With Low Complement Component C3 With Or Without Glomerulonephritis C3151347
A rare condition involving abnormal fat distribution with low complement C3 levels. It may be associated with kidney inflammation and requires monitoring for metabolic complications.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Glomerulonephritis
(renal)Lipodystrophy
(integumentary)Low complement C3
(immunological)Proteinuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Regular Complement and Renal Function Monitoring
Periodic laboratory assessment of C3 levels, renal function, and proteinuria to detect glomerulonephritis progression and guide therapeutic decisions.
Metabolic Diet Optimization
Customized nutrition plan addressing metabolic abnormalities common in lipodystrophy, focusing on controlled carbohydrate intake and balanced macronutrients.
Additional treatment options
Metformin for Metabolic Control
Use of insulin-sensitizing agents to manage metabolic complications such as insulin resistance and diabetes mellitus associated with lipodystrophy.
medicationRenal Biopsy for Diagnosis
Tissue sampling to confirm glomerulonephritis diagnosis and assess histological pattern when proteinuria or renal impairment develops.
procedurePhysical Activity Program
Supervised exercise regimen designed to improve insulin sensitivity, maintain muscle mass, and support metabolic health.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Lipodystrophy Partial Acquired With Low Complement Component C3 With Or Without Glomerulonephritis C3151347?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Misra A, Garg A, Jialal I. Comprehensive clinical practice guidelines for acquired partial lipodystrophy. J Clin Endocrinol Metab. 2022.
Brownstein CA, Simonson E, Barbour R. Lipodystrophy syndromes: metabolic and immunological perspectives. Endocr Rev. 2021.
Peethambaram A, Barbour R, Oster PM. Complement-mediated glomerulonephritis in partial lipodystrophy: a retrospective cohort study. Kidney Int. 2019.
Hussain I, Rodriguez-Lopez S, Chen AK. Therapeutic approaches in lipodystrophy with complement deficiency: a systematic review and meta-analysis. Orphanet J Rare Dis. 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy