Lissencephaly 4 C3151461
A severe brain malformation where the brain surface is unusually smooth due to abnormal brain development. It causes significant developmental delays and neurological problems. Care focuses on symptom management and supportive therapies.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Recurrent seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe developmental delay
(neurologic)Microcephaly
(neurologic)Spastic quadriplegia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antiepileptic drug therapy
Seizure control is essential in lissencephaly management. Antiepileptic medications are prescribed based on seizure type and frequency, with regular monitoring for efficacy and side effects.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Neurodevelopmental monitoring
Regular assessments of developmental milestones, motor function, and cognitive progress through pediatric neurology and developmental pediatrics consultations to guide intervention timing.
Additional treatment options
Motor function therapy
Specialized physical therapy programs focus on improving muscle tone, preventing contractures, and enhancing mobility through targeted exercises and positioning techniques.
physical_therapyGastrostomy tube placement
For patients with significant feeding difficulties or aspiration risk, surgical placement of a feeding tube ensures adequate nutrition and medication administration.
surgicalFamily counseling and support
Psychological support for families addresses the emotional challenges of caring for a child with severe developmental disability, including counseling and connection to support networks.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly 4 C3151461?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Lissencephaly 4 C3151461. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy