Lissencephaly 6 With Microcephaly C4015525
A brain malformation causing a smooth brain surface along with an abnormally small head. It leads to severe developmental delays and neurological impairment. Treatment involves supportive care and therapies.
Key facts at a glance
- ICD-10
- Q02
- ICD-11
- LA00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Frequent seizures
Recurrent aspiration pneumonia
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe intellectual disability
(neurologic)Marked microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Seizure management protocol
Comprehensive antiepileptic therapy tailored to the specific seizure presentation associated with lissencephaly-6, often requiring combination therapy for adequate control.
Head circumference and neuroimaging surveillance
Regular monitoring of head growth velocity and periodic MRI imaging to assess progression of microcephaly and any associated complications.
Additional treatment options
Early intervention physical therapy
Intensive motor and developmental therapy initiated early to maximize functional potential and address hypotonia commonly seen with microcephaly.
physical_therapyNutritional optimization
Dietary management ensuring adequate calories and micronutrients to support growth and development, particularly important given feeding challenges.
dietaryHydrotherapy
Water-based therapy providing resistance and support for movement exercises, which can be particularly beneficial for patients with motor limitations.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly 6 With Microcephaly C4015525?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy