Lissencephaly With Cerebellar Hypoplasia Type B C4274993
A form of lissencephaly combined with cerebellar hypoplasia caused by specific genetic changes. It presents in infancy with severe neurological and motor challenges. Treatment is supportive and focuses on quality of life.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Hypotonia
(neurologic)Ataxia
(neurologic)Microcephaly
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Intensive Motor Intervention Program
Early intervention physical therapy focusing on movement patterns, balance training, and muscle tone management to maximize motor development potential in patients with lissencephaly and cerebellar hypoplasia.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Comprehensive Neurological Monitoring
Regular neurological assessments including EEG, MRI follow-up, and developmental milestone tracking to monitor disease progression and detect complications such as seizure activity.
Additional treatment options
Anticonvulsant Therapy
Seizure management through appropriate anticonvulsant medications when clinically indicated, selected based on seizure type and patient tolerability.
medicationNutritional Support Program
Individualized nutritional planning addressing feeding difficulties, weight management, and ensuring adequate caloric and nutrient intake for optimal growth and development.
dietaryFamily Counseling and Support Services
Psychological support for families including counseling, education about the condition, and connection to support networks to address the emotional impact of caring for a child with severe developmental disability.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly With Cerebellar Hypoplasia Type B C4274993?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy