Lissencephaly With Cerebellar Hypoplasia Type C C4274992
A genetic brain malformation involving smooth brain surface and small cerebellum. It causes significant developmental delays and motor problems in children. Management requires comprehensive, ongoing supportive care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Developmental delay
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cerebellar hypoplasia
(neurologic)Spasticity
(neurologic)Feeding difficulties
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Neurodevelopmental Therapy
Specialized therapy combining physical and occupational therapy approaches to address motor delays, improve coordination, and support functional abilities in patients with combined lissencephaly and cerebellar involvement.
Multidisciplinary Developmental Surveillance
Coordinated care with neurology, developmental pediatrics, and allied health professionals to track developmental progress, adjust interventions, and screen for associated complications.
Additional treatment options
Gastrostomy Tube Placement
Surgical placement of feeding tube for patients with significant dysphagia or feeding difficulties to ensure adequate nutrition and medication administration.
surgicalSpasticity Management
Pharmacological management of increased muscle tone using muscle relaxants, with selection and dosing guided by severity and response to treatment.
medicationHydrotherapy Sessions
Water-based therapy providing resistance training, relaxation, and gentle exercise in a supported environment to improve mobility and reduce muscle stiffness.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly With Cerebellar Hypoplasia Type C C4274992?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Lissencephaly With Cerebellar Hypoplasia Type C C4274992. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy