Lissencephaly With Cerebellar Hypoplasia Type E C5191422
A complex brain malformation involving abnormal brain folding and cerebellar underdevelopment. It leads to severe neurological deficits in affected children. Care focuses on supportive measures and symptom management.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Intractable seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Severe motor impairment
(neurologic)Feeding difficulties
(neurologic)Respiratory distress
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Functional Movement Therapy
Therapeutic exercises and positioning strategies to maintain joint mobility, prevent contractures, and support the highest possible level of functional independence.
Respiratory Function Assessment
Regular monitoring of respiratory function due to cerebellar involvement affecting breathing control, including sleep studies when indicated.
Additional treatment options
Respiratory Support Medications
Pharmacological management of respiratory symptoms including secretions, bronchospasm, or obstructive sleep apnea associated with cerebellar dysfunction.
medicationSleep-Disordered Breathing Intervention
Surgical evaluation and treatment for obstructive sleep apnea or other sleep-disordered breathing conditions that may accompany cerebellar hypoplasia.
surgicalEnvironmental Modifications and Assistive Devices
Home and environmental adaptations including positioning equipment, mobility aids, and communication devices to maximize independence and safety.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Lissencephaly With Cerebellar Hypoplasia Type E C5191422?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Lissencephaly With Cerebellar Hypoplasia Type E C5191422. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy