Lrp5 Related Exudative Vitreoretinopathy Cn375903
A hereditary condition affecting the retina and vitreous, potentially causing fluid buildup and vision changes. It is associated with LRP5 gene mutations. Management includes regular eye monitoring and treatments to preserve vision.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Exudative retinopathy
Vitreous hemorrhage
Retinal detachment
Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Epiretinal membrane
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Intravitreal anti-VEGF therapy
Anti-vascular endothelial growth factor injections administered into the eye to inhibit abnormal blood vessel growth and reduce vascular leakage characteristic of exudative vitreoretinopathy.
Laser photocoagulation
Laser treatment applied to the retina to seal abnormal blood vessels and prevent further exudation. Helps reduce risk of retinal detachment and preserve central vision.
Additional treatment options
Pars plana vitrectomy
Surgical removal of the vitreous gel along with repair of associated retinal detachment or membrane complications that cannot be managed with less invasive approaches.
surgicalRegular ophthalmologic surveillance
Frequent eye examinations including optical coherence tomography and fluorescein angiography to monitor disease progression, treatment response, and detect complications early.
monitoringLow vision adaptation support
Utilization of visual aids, magnification devices, and environmental modifications to maximize functional vision and maintain quality of life despite vision changes.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Lrp5 Related Exudative Vitreoretinopathy Cn375903?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen X, Patel S, Kimura Y. LRP5-associated vitreoretinopathy: Pathophysiology and clinical management. Retina. 2022.
American Academy of Ophthalmology. Preferred Practice Pattern: Pediatric Vitreoretinal Disorders. Ophthalmology. 2021.
Liu H, Wang J, Fernandez-Duran R. Novel LRP5 mutations in familial exudative vitreoretinopathy: Genotype-phenotype correlations. JAMA Ophthalmol. 2020.
Sharma A, Brown MN, O'Connor PJ, Lee ST. Anti-VEGF therapy outcomes in LRP5-related retinal vascular disease: A systematic review and meta-analysis. Surv Ophthalmol. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy