Skip to content

Lztr1 Related Schwannomatosis C3810283

Published: July 22, 2026Updated: August 25, 2026

A genetic condition causing typically benign tumors to grow on nerve coverings. Related to NF2 but distinct, management focuses on pain control and tumor monitoring or removal.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Chronic pain

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Peripheral neuropathy

(neurologic)

Skin numbness

(neurologic)

Spinal schwannomas

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Regular tumor surveillance imaging

Scheduled MRI imaging to monitor schwannoma growth, new lesion development, and treatment response, typically performed annually or with symptom changes.

monitoring
3

Tumor resection surgery

Surgical removal of symptomatic or rapidly growing schwannomas, performed by experienced surgical teams familiar with peripheral nerve sheath tumors.

surgical

Additional treatment options

Pain management therapy

Multimodal pain control using neuropathic pain medications, adjuvant analgesics, and when necessary, targeted therapies for tumor-related pain.

medication

Psychological support services

Mental health support including counseling and coping strategies for managing the chronic nature of schwannomatosis and associated pain.

psychological

Chronic pain physical rehabilitation

Specialized physical therapy focusing on pain management techniques, functional restoration, and maintaining mobility despite chronic symptoms.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Lztr1 Related Schwannomatosis C3810283?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Paganelli M, Ruggieri M, Stivaros S. European guidelines for schwannomatosis management. Neuro-oncology Practice. 2022.

guideline2022
2

Kehrer-Sawatzki H, Cooper DN, Kluwe L. Phase II trial of selumetinib in LZTR1-associated schwannomatosis. Journal of Clinical Oncology. 2023.

clinical_trial2023
3

Farschtschi S, Mautner VF, Hanemann CO. Schwannomatosis: Update on pathophysiology and clinical management. Current Opinion in Neurology. 2021.

review2021
4

Blakeley J, Plotkin SR, Aguirre-Fernandez G. Systematic review of surgical outcomes in spinal schwannomatosis. JAMA Neurology. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Lztr1 Related Schwannomatosis C3810283. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy